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Sactivation of PDGFR, and PI3K/JNK/c-Jun (AP-1). Moreover, LTAinduced MMP-9 expression is positively associated with cell motility (migration) in the RBA-1 cell culture model.MethodsMaterialsDMEM/F-12 medium, FBS, and TRIzol were from Invitrogen (Carlsbad, CA, USA). Hybond C membrane and ECL western blotting detection system were from GE Healthcare Bio-sciences (Buckinghamshire, UK). MMP-9 antibo
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On of these signalingcascades and transcription factors has been reported to be involved in induction of MMP-9 in rat astrocytes [20,24,25]. Moreover, transactivation of receptor tyrosine kinases such as platelet-derived growth factor receptor (PDGFR) by several stimuli has also been implicated in mediating cellular functions of glial cells [29]. More recently, we have demonstrated that LTA induc
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